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Jack R. Lancaster, Jr.

Professor of Pharmacology and Chemical Biology,

Medicine, and Surgery




16478 Timberlakes Dr. #203

Fort Myers, FL 30398



E13588 Thomas E. Starzl

Biomedical Science Tower

200 Lothrop St.

Pittsburgh, PA 15261

Business Phone: 412-648-9319

FAX: 412-648-2229

Mobile Phone: 412-303-0591





Biological roles of nitric oxide and reactive oxygen species:

Basic studies:

  • Biochemistry and molecular biology of NO and its interactions at the cellular and subcellular levels; cultured cells (hepatocytes, erythrocytes, lymphocytes, mammalian cell lines, bacteria) and isolated proteins (iron-sulfur proteins, electron transferring enzymes, nonheme iron) and membranes; roles of NO in autophagy

  • Dynamics of NO in blood and tissue: Kinetics, modeling

Biomedical studies:

  • Roles of NO in injury (inflammation, infection, ischemia/reperfusion) dealing particularly with interactions between NO and reactive oxygen species.

  • Hemoglobin in blood as a major determinant of the biomedical actions of NO

  • Biological mechanisms of nitrosation from NO

  • Mechanisms of NO in cancer signaling

Techniques and applications:

  • Electron paramagnetic resonance spectroscopy for in vitro and in vivo detection of NO and its actions

  • Electrochemical detection of NO

  • Chemiluminescent detection of nitrogen oxides in biological samples

  • Determination of enzymatic, cellular, organ, and organismal damage from reactive oxygen intermediates

  • Measurement of cellular enzymatic activities (including the enzymatic synthesis of NO), spectroscopic properties, and metabolism

  • Methodologies in membrane biochemistry/biophysics

  • Computer modeling of diffusion/reaction


Molecular mechanisms of enzyme-catalyzed electron transfer and biological energy transfer:

  • Conservation of energy coupling in electron transfer and membrane transport of solutes and ions




Dates Attended Name and Location of Institution Degree Received and Year Major Subject



Sept. 1966-May1967,  Purdue University, W. Lafayette, IN — Chemistry


September 1967- August 1970,  University of Tennessee at Martin, Martin, TN 1970 — B.S. Chemistry 


Dates Attended Name and Location of Institution Degree Received and Year Major Professor and Discipline



September 1970-May 1974 University of Tennessee Center for the Health Sciences, Memphis, TN Ph.D., 1974 Dr. Robert J. Hill, Biochemistry


Dates Attended Name and Location of Institution Name of Program Director and Discipline

Post Graduate:


September 1974-August 1976

Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY Dr. Peter C. Hinkle--Biochemistry


September 1976-July 1980

Department ofBiochemistry, Duke University School of Medicine, Durham, NC Dr Henry Kamin (deceased) --Biochemistry




Years Inclusive Name and Location of Institution or Organization Title


1980-1992 Department of Chemistry and Biochemistry

Utah State University Assistant Professor

1980-1983 Associate Professor (Tenured), 1983-1992


1987-88 Department of Microbiology and Immunology

Emory University School of Medicine Sabbatical Leave (with Dr. Linda R. Gooding)


1992-1994 Departments of Surgery and Anesthesiology and Critical Care Medicine

University of Pittsburgh School of Medicine, Associate Professor


1993-1994 Department of Pharmacology, University of Pittsburgh School of Medicine, Associate Professor

1994-1997 Departments of Physiology and Medicine, LSU Medical Center, Associate Professor

1997-2002 Departments of Physiology and Medicine, LSU Medical Center, Professor


2002-2014 Departments of Anesthesiology, Physiology & Biophysics, and Environmental Health Sciences

University of Alabama at Birmingham, Professor


2013-Pr. Departments of Pharmacology and Chemical Biology, 

Medicine, and Surgery, University of Pittsburgh School of Medicine, Professor


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