CURRICULUM VITAE
Jack R. Lancaster, Jr.
Professor of Pharmacology and Chemical Biology,
Medicine, and Surgery
CITIZENSHIP: US
HOME ADDRESS:
16478 Timberlakes Dr. #203
Fort Myers, FL 30398
BUSINESS ADDRESS:
E13588 Thomas E. Starzl
Biomedical Science Tower
200 Lothrop St.
Pittsburgh, PA 15261
Business Phone: 412-648-9319
FAX: 412-648-2229
Mobile Phone: 412-303-0591
Email: doctorno@pitt.edu
RESEARCH INTERESTS:
Biological roles of nitric oxide and reactive oxygen species:
Basic studies:
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Biochemistry and molecular biology of NO and its interactions at the cellular and subcellular levels; cultured cells (hepatocytes, erythrocytes, lymphocytes, mammalian cell lines, bacteria) and isolated proteins (iron-sulfur proteins, electron transferring enzymes, nonheme iron) and membranes; roles of NO in autophagy
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Dynamics of NO in blood and tissue: Kinetics, modeling
Biomedical studies:
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Roles of NO in injury (inflammation, infection, ischemia/reperfusion) dealing particularly with interactions between NO and reactive oxygen species.
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Hemoglobin in blood as a major determinant of the biomedical actions of NO
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Biological mechanisms of nitrosation from NO
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Mechanisms of NO in cancer signaling
Techniques and applications:
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Electron paramagnetic resonance spectroscopy for in vitro and in vivo detection of NO and its actions
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Electrochemical detection of NO
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Chemiluminescent detection of nitrogen oxides in biological samples
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Determination of enzymatic, cellular, organ, and organismal damage from reactive oxygen intermediates
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Measurement of cellular enzymatic activities (including the enzymatic synthesis of NO), spectroscopic properties, and metabolism
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Methodologies in membrane biochemistry/biophysics
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Computer modeling of diffusion/reaction
Molecular mechanisms of enzyme-catalyzed electron transfer and biological energy transfer:
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Conservation of energy coupling in electron transfer and membrane transport of solutes and ions
EDUCATION AND TRAINING:
Dates Attended Name and Location of Institution Degree Received and Year Major Subject
Undergraduate:
Sept. 1966-May1967, Purdue University, W. Lafayette, IN — Chemistry
September 1967- August 1970, University of Tennessee at Martin, Martin, TN 1970 — B.S. Chemistry
Dates Attended Name and Location of Institution Degree Received and Year Major Professor and Discipline
Graduate:
September 1970-May 1974 University of Tennessee Center for the Health Sciences, Memphis, TN Ph.D., 1974 Dr. Robert J. Hill, Biochemistry
Dates Attended Name and Location of Institution Name of Program Director and Discipline
Post Graduate:
September 1974-August 1976
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY Dr. Peter C. Hinkle--Biochemistry
September 1976-July 1980
Department ofBiochemistry, Duke University School of Medicine, Durham, NC Dr Henry Kamin (deceased) --Biochemistry
APPOINTMENTS AND POSITIONS
Years Inclusive Name and Location of Institution or Organization Title
1980-1992 Department of Chemistry and Biochemistry
Utah State University Assistant Professor
1980-1983 Associate Professor (Tenured), 1983-1992
1987-88 Department of Microbiology and Immunology
Emory University School of Medicine Sabbatical Leave (with Dr. Linda R. Gooding)
1992-1994 Departments of Surgery and Anesthesiology and Critical Care Medicine
University of Pittsburgh School of Medicine, Associate Professor
1993-1994 Department of Pharmacology, University of Pittsburgh School of Medicine, Associate Professor
1994-1997 Departments of Physiology and Medicine, LSU Medical Center, Associate Professor
1997-2002 Departments of Physiology and Medicine, LSU Medical Center, Professor
2002-2014 Departments of Anesthesiology, Physiology & Biophysics, and Environmental Health Sciences
University of Alabama at Birmingham, Professor
2013-Pr. Departments of Pharmacology and Chemical Biology,
Medicine, and Surgery, University of Pittsburgh School of Medicine, Professor