Jack R Lancaster, Jr. PhD
My Journey as a Scientist
Literature Cited
1. J. R. Lancaster, jr., R. J. Hill, and W. G. Struve (1975) "The Character-ization of Energized and
Partially De‐Energized (Respiration‐-Independent) β‐Galac-toside Transport in Escherichia coli"
Biochim. Biophys. Acta 401, 285-298.
2. J. R. Lancaster, jr. and P. C. Hinkle (1977) "Studies of the β‐Galacto-side Transporter
in Inverted Membrane Vesicles of E. coli. I. Symmetrical Facilitated Diffusion and Proton
Gradient‐Coupled Trans-port" J. Biol. Chem. 252, 7657-7661.
3. J. R. Lancaster, jr. and P. C. Hinkle (1977) "Studies of the β‐Galacto-side Transporter in
Inverted Membrane Vesicles of E. coli. II. Symmetrical Binding of a Dansylgalactoside Induced
by an Electrochemical Proton Gradient and by Lactose Efflux" J. Biol. Chem. 252, 7662-7666.
4. J. R. Lancaster, jr. (1978) "Site‐Exposure Model for Proton‐Lactose Symport in E. coli" J.
Theor. Biol. 75, 35-50.
5. J. R. Lancaster, jr. (1982) "Mechanism of Lactose‐Proton Cotran-sport in E. coli: Kinetic
Results in Terms of the Site Exposure Model" FEBS Lett. 150, 9-18
6. J. R. Lancaster, jr., J. Vega, H. Kamin, N. Orme‐Johnson, W. H. Orme--Johnson, R. Krueger,
and L. M. Siegel (1979) "Identification of the Iron--Sulfur Center of Spinach Ferredoxin‐Nitrite
Reductase as a Tetranuclear Center, and Prelimi-nary EPR Studies of Mechanism" J. Biol. Chem.
7. J. R. Lancaster, jr., C. J. Batie, H. Kamin, and D. B. Knaff (1982) "Purifi-cation of Spinach Nitrite
Reductase" In: Methods in Chloroplast Molecular Biology (M. Edelman, R. B. Hallick, and N. H.
Chua,eds.) pp 723‐734.
8. D. W. Seybert, J. R. Lancaster, jr., J. D. Lambeth, and H. Kamin (1979) "Partici-pation of the
Membrane in Side‐Chain Cleavage of Cholesterol. Recons-titution of Cytochrome P450scc
Adrenal Cortex Mitochondria into Phospho-lipid Vesicles" J. Biol. Chem. 254, 12088-12098.
9. J. D. Lambeth, J. R. Lancaster, jr., D. W. Seybert, and H. Kamin (1980) "Binding of Cholesterol
and Adrenodoxin to Phospholipid Vesicle Reconstitu-ted P450scc" In: Microsomes, Drug
Oxidations, and Chemical Carcinogenesis" (M. J. Coon, A. W. Conney, R. W. Estabrook, H. V.
Gelboin, J. R. Gillette, and P. J. O'Brien, eds.) pp 553‐557.
10. J. D. Lambeth, J. R. Lancaster,jr., and H. Kamin (1981) "Steroido-genic Electron Transport by
Adrenodoxin Reductase and Adrenodoxin: Use of Acety-lated Cytochrome c as a Mechanistic
Probe of Electron Transfer" J. Biol. Chem. 256, 3674-3678.
11. J. D. Lambeth, D. W. Seybert, J. R. Lancaster, jr., J. C. Salerno and H. Kamin (1982)
"Steroidogenic Electron Transport in Adrenal Cortex Mitochon-dria" Molec. Cell. Biochem. 45,
12. H. Kamin, C. Batie, J. D. Lambeth, J. Lancaster, L. Graham, and J. C. Salerno (1985)
"Paramagnetic Probes of Multicomponent Electron‐Tran-sfer Systems", Biochem. Soc. Trans.
13. J. R. Lancaster, jr. (1980) "Soluble and Membrane‐Bound Paramagnetic Centers in
Methanobacterium bryantii" FEBS Lett. 115, 285-288.
14. J. R. Lancaster, jr. (1982) "New Biological Paramagnetic Center: Octahed-rally Coordinated
Ni(III) in the Methanogenic Bacteria" Science 216, 1324-1325.
15. J. R. Lancaster, jr. (1982) "Identification and Detection of Electron Transfer Components in
Methanogens" Meth. Enz. 88, 412-417.
16. A. J. Thomson (1982) “Proteins Containing Nickel” Nature 298. 602-603
17. J. R. Lancaster, jr. (1988) "The Bioinorganic Chemistry of Nickel", Editor, VCH Publishers.
18. D. J. Ecker, J. R. Lancaster, jr., and T. Emery (1982) "Siderophore Iron Transport Followed by
Electron Paramagnetic Resonance Spectros-copy" J. Biol. Chem. 257, 8623-8626.
19. J. R. Lancaster, jr. (1981) "Membrane‐Bound Flavin Adenine Dinucleotide in
Methanobacterium bryantii" Biochem. Biophys. Res. Comm. 100, 240-246.
20. T. W. Kirby, J. R. Lancaster, jr., and I. Fridovich (1981) "Isola-tion and Characterization of
the Iron‐Containing Superoxide Dismutase of Methanobacterium bryantii" Arch. Biochem.
Biophys. 210, 140-148.
21. J. R. Lancaster, jr., K. Gillies, and K. R. Rogers (1985) "Bioener-getic Role of Nickel‐containing
Proteins in Methano-gens" Rev. Port. Quim. 27, 73-75.
22. B. P. Crider, S. W. Carper, and J. R. Lancaster,jr. (1985) "Electron Transfer‐Driven ATP
Synthesis in Methanococcus voltae is Not Dependent on a Proton Electrochemical Gradient",
Proc. Natl. Acad. Sci. USA 82, 6793-6796.
23. J. R. Lancaster, jr. (1986) "A Unified Scheme for Carbon and Electron Flow Coupled to ATP
Synthesis by Substrate Level Phosphoryla-tion in the Methanogenic Bacteria" FEBS Lett. 199,
24. S. W. Carper and J. R. Lancaster, jr. (1986) " An Electrogenic Sodium‐-translocating ATPase in
Methanococcus voltae", FEBS Lett. 200, 177-180
25. H. A. Al‐Mahrouq, S. W. Carper, and J. R. Lancaster, jr. (1986) "Dis-crimination Between
Transmembrane Ion Gradient‐Driven and Electron Transfer--Driven ATP Synthesis in the
Methanogenic Bacteria", FEBS Lett. 207, 262-265.
26. J. R. Lancaster, jr.,S. W. Carper, B. P. Crider, K. Gillies, and K. R. Rogers (1986) "Bioenergetic
Role of Nickel‐containing Proteins in Methano-gens", in Frontiers in Bioinorganic Chemistry, A.
V. Xavier, ed., VCH Publishers, pp. 27-35.
27. K. R. Rogers, K. Gillies, and J. R. Lancaster, jr. (1988) "Iron-Sulfur Centers Involved in Electron
Transfer in Methanobacterium thermoautotrophicum" Biochem. Biophys. Res. Comm. 153, 87-
28. J. R. Lancaster, jr. (1987) "ATP Synthesis and Ion Gradients in the Methano-genic Bacteria",
in Advances in Membrane Biochemistry and Bioenergetics, C. H. Kim, H. Tedeschi, J. J. Diwan,
and J. C. Salerno, eds., Plenum Press, pp. 363-387.
29. J. R. Lancaster, jr. (1989) "Sodium, Protons, and Energy Coupling in the Methanogenic
Bacteria" J. Bioenerg. Biomemb. 21, 717-740 (invited review).
30. D. Reddy, J. R. Lancaster, jr., and D. P. Cornforth (1983) "Nitrite Inhibition of Clostridium
botulinum: Electron Spin Resonance Detection of Iron‐Nitric Oxide Complexes" Science 221,
31. J. R. Lancaster, jr., S. M. Laster, and L. R. Gooding (1989) "Inhibition of Target Cell
Mitochondrial Electron Transfer by Tumor Necrosis Factor" FEBS Lett. 248, 169-174.
32. J. R. Lancaster, jr., and J. B. Hibbs, jr., (1990) "EPR Demonstration of Iron-Nitrosyl Complex
Formation by Cytotoxic Activated Macrophages", Proc. Natl. Acad. Sci. USA, 87, 1223-1227.
33. J. R. Lancaster, Jr., J. M. Langrehr, H.A. Bergonia, N. Murase, R. L. Simmons, and R. A.
Hoffman (1992) “EPR Detection of Heme and Nonheme Iron-Containing Protein Nitrosylation by
Nitric Oxide during Rejection of Rat Heart Allograft”, J. Biol. Chem. 267, 10994-10998.
34. J. M. Langrehr, A.R. Müller, H. Bergonia, T. Jacobs, W.H. Schraut, J. R. Lancaster, Jr., R.A.
Hoffman, and R. L. Simmons (1992) “Detection of Nitric Oxide by EPR Spectroscopy During
Rejection and Graft-Versus-Host Disease Following Small Bowel Transplantation in the Rat”
Surgery 112, 395-402.
35. J. A. Corbett, J. R. Lancaster, jr., M. A. Sweetland, and M. L. McDaniel (1991) “Interleukin-
1β-induced Formation of EPR-Detectable Iron-Nitrosyl Complexes in Islets of Langerhans. Role
of Nitric Oxide in Interleukin-1β-induced Inhibition of Insulin Secretion” J. Biol. Chem. 266,
36. J. A. Corbett, R. G. Tilton, K. Chang, K. S. Hasan, Y. Ido, J. L. Wang, M. A. Sweetland, J. R.
Lancaster, Jr., J. R. Williamson, and M. L. McDaniel (1992) “Aminoguanidine, a Novel Inhibitor of
Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction” Diabetes 41, 552-556.
37. L. J. Nixon-Heiss, J. R. Lancaster, Jr., J. A. Corbett, and W. E. Goldman (1994) “Epithelial
Autotoxicity of Nitric Oxide: Role in the Respiratory Cytopathology of Pertussis”, Proc. Natl.
Acad. Sci. USA 91, 267-270.
38. J. Stadler, H. A. Bergonia, M. Di Silvio, M. A. Sweetland, T. R. Billiar, R. L. Simmons, and J. R.
Lancaster, Jr. (1993) “Nonheme Iron-Nitrosyl Complex Formation in Rat Hepatocytes: Detection
by Electron Paramagnetic Resonance Spectroscopy” Arch. Biochem. Biophys. 302, 4-11.
39. J. R. Lancaster, Jr., G. Werner-Felmayer, and H. Wachter (1994) “ Coinduction of Nitric Oxide
Synthesis and Intracellular Nonheme Iron-Nitrosyl Complexes in Murine Cytokine-Treated
Fibroblasts” Free Rad. Biol. Med. 16, 869-870.
40. MS Joshi, JL Ponthier, and JR Lancaster, Jr. (1999) “Cellular Antioxidant and Prooxidant
Actions of Nitric Oxide” Free Rad. Biol. Med. 27, 357-1366.
41. Y-M. Kim, H. Bergonia, J. R. Lancaster, Jr. (1995) “Nitrogen Oxide-Induced Autoprotection in
Isolated Rat Hepatocytes” FEBS Lett 374, 228-232.
42. Y-M. Kim, H. A. Bergonia, B. R. Pitt, W. D. Watkins, and J. R. lancaster, Jr. “Loss and
Degradation of Enzyme-Bound Heme Induced by Cellular Nitric Oxide Synthesis” J. Biol. Chem.
43.Y-M. Kim, H. A. Bergonia, C. M. Müller, B. R. Pitt, W. D. Watkins, and J. R. Lancaster, Jr.
(1995) “Nitric Oxide and Intracellular Heme” Adv. Pharmacol. 34:277-291.
44. M. A. Schwarz, J. S. Lazo, J. C. Yalowich, W. P. Allen, M. Whitmore, H. A. Bergonia, Lancaster,
Jr. (1995) “Metallothionein Protects Against the Cytotoxic and DNA Damaging Effects of Nitric
Oxide” Proc. Natl. Acad. Sci. USA 92, 4452-4456.
45. 33. Y-M Kim, JR Lancaster, Jr. (1993) “Tetrahydrobiopterin-Dependent Nitrite Oxidation to
Nitrate in Isolated Rat Hepatocytes” FEBS Lett. 332: 255-259.
46. J. R. Lancaster, Jr. (1992) “Nitric Oxide in Cells” American Scientist 80:248-259
47. J. R. Lancaster, Jr. (1994) “ Simulation of the Diffusion and Reaction of Endogenously
Produced Nitric Oxide” Proc. Natl. Acad. Sci. USA 91:8137-8141.
48. J. R. Lancaster, Jr. (1996) “Diffusion of Free Nitric Oxide” Meth. Enz. 268:31-50
49. J. R. Lancaster, Jr. “A Tutorial on the Diffusibility and Reactivity of Free Nitric Oxide” Nitric
50. JR Lancaster, jr. (2000) “The Physical Properties of Nitric Oxide: Determinants of the
Dynamics of NO in Tissue. in Nitric Oxide: Biology and Pathobiology Ignarro, LJ, ed. Academic
Press, San Diego, CA pp 209-224
51. X. Liu, M.J. S. Miller, M. S. Joshi, H. Sadowska-Krowicka, D. A. Clark, and J. R. Lancaster,
Jr. (1998) “Diffusion-Limited Reaction of Free Nitric Oxide with Erythrocytes” J. Biol. Chem.
52. J. R. lancaster, Jr. Sickle Cell Disease: Loss of the Blood’s WD40? Trends Pharmacol. Sci.
53. DD Thomas, X Liu, SP Kantrow, JR Lancaster, Jr. (2001) “The Biological Lifetime of Nitric
Oxide: Implications for the Perivascular Dynamics of NO and O2” Proc. Natl. Acad. Sci. USA 98:
54. Joshi, MS, Ferguson, Jr., TB, Han, TH, Hyduke, DR, Liao, JC, Rassaf, T, Bryan, N, Feelisch,
M, and Lancaster, Jr., JR “Nitric Oxide is Consumed, Rather than Conserved, by Reaction with
Oxyhemoglobin under Physiological Conditions”. Proc. Natl. Acad. Sci. USA 99:10341-10346
55. Gladwin, MT, Lancaster, Jr., JR, Freeman, BA, & Schechter, AN “Nitric Oxide Reactions with
Hemoglobin: A View Through the SNO-Storm”. Nature Med 9:496-500 (2003).
56. X. Liu, M. J. S. Miller, M. S. Joshi, D. D. Thomas, and J. R. Lancaster, Jr. (1998) “Accelerated
Reaction of Nitric Oxide with O2 within the Hydrophobic Interior of Biological Membranes”
Proc. Natl. Acad. Sci. USA 95:2175-2179.
57. M. N. Möller, Q. Li, D. A. Vitturi, J. M. Robinson, J. R. Lancaster Jr., and A. Denicola (2007)
“Membrane ‘Lens’ Effect: Focusing the Formation of Reactive Nitrogen Oxides from the •NO/O2
Reaction” Chem. Res. Toxicol. 20:709714
58. J. C. Toledo, C. A. Bosworth, S. W. Hennon, and J. R. Lancaster, Jr. (2008) “Nitric Oxide-
Induced Conversion of Cellular Chelatable Iron into Macromolecule-Bound Dinitrosyliron
Complexes” J. Biol Chem. 2008;283:2892659.
59. Lancaster, Jr., JR (2006) “Nitroxidative, Nitrosative, and Nitrative Stress: Kinetic Predictions
of Reactive Nitrogen Species Chemistry Under Biological Conditions” Chem. Res. Toxicol.
60. Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation
from nitric oxide. Bosworth CA, Toledo JC Jr, Zmijewski JW, Li Q, Lancaster JR Jr. Proc Natl Acad
Sci U S A. 2009;106:4671.
61. Q. Li, C. Li, H.K. Mahtani, J. Du, A.R. Patel, J.R. Lancaster Jr. “Nitrosothiol Formation and
Protection against Fenton Chemistry by Nitric Oxide-Induced Dinitrosyliron Complex Formation
from Anoxia-Initiated Cellular Chelatable Iron Increase” J. Biol. Chem. 2014 in press.
62. J. R. Lancaster, Jr., L. J. Ignarro, Free Rad. Biol. Med. 25:384
63. J. M. Langrehr, R. A. Hoffman, J. R. Lancaster, Jr., and R. L. Simmons (1993) “Nitric Oxide: A
New Endogenous Immunomodulator” Transplantation 55:1205-1212
64. C. H. Evans, M. Steanovic-Racic, and J. R. Lancaster, Jr. (1995) “Nitric Oxide and its Role in
Orthopaedic Disease” Clin. Orthop. Rel. Res. 312:275-294.
65. J. F. Kerwin, Jr., J. R. Lancaster, Jr., and P. L. Feldman (1995) “Nitric Oxide: A New Paradigm
for Second Messengers” J. Med. Chem. 38:4343-4362.
66. J. B. Hibbs, Jr., R. R. Taintor, Z. Vavrin, D. L. Granger, J-C. Drapier, I. J. Amber, and J. R.
Lancaster, Jr. (1990) “Synthesis of Nitric Oxide from a Terminal Guanidino Nitrogen Atom of L-
Arginine: a Molecular Mechanism Regulating Cellular Proliferation that Targets Intracellular
Iron” in Nitric Oxide from L-Arginine: a Bioregulatory System Moncada, S, & Higgs, EA, eds.,
Elsevier pp189-223
67. P. D. Freeswick, D. A. Geller, J. R. Lancaster, Jr., and T. R. Billiar (1994) “Nitric Oxide and
the Liver” in The Liver: Biology and Pathobiology 3rd ed. Arias I,Boyer J, Fausto N, Jakoby W,
Schachter D, Shafritz D, eds, Raven Press, New York, NY pp 1031-1045
68. J. R. Lancaster, Jr. (1994) “The Biology of Nitric Oxide” in Encyclopedia of Inorganic
Chemistry King RB, ed., Wiley pp 2482-2498
69. Y-M. Kim, T. R. Billiar, and J. R. Lancaster, Jr. “Reactive Oxygen and Nitrogen Metabolites
and Related Enzymes. Kim,Y-M, Billiar, TR, and Lancaster, JR Jr. Handbook of Experimental
Immunology, 1999.
70. D. J. Singel, J. R. Lancaster, Jr. (1996) “EPR Spectroscopy and NO Biology”. In Methods in
Nitric Oxide Research, Feelisch, M, Stamler, JS, eds., Wiley, NY pp 341-356.
71. J. R. Lancaster, Jr., and D. J. Stuehr (1996) “The Intracellular Reactions of Nitric Oxide in the
Immune System and its Enzymatic Synthesis” in Nitric Oxide: Principles and Actions Lancaster JR
Jr., ed., Academic Press, San Diego, CA pp139-175
72. M. S. Joshi, and J. R. Lancaster, Jr. (1997) “Free Radicals and Disease” in Encyclopedia of
Human Biology, 2nd ed. Dulbecco R, ed., Academic Press, San Diego, CA pp 107-114
73. J. R. Lancaster, Jr. (1997) “Interaction of NO with Iron-dependent Enzymes” in Ernst
Schering Research Foundation Workshops Lancaster, Jr., JR, & Parkinson, JF, eds., Springer,
74. J. R. Lancaster, Jr., ed. (1996) “Nitric Oxide: Principles and Actions”, Academic Press.
75. J. R. Lancaster, Jr., and J. F. Parkinson (1997) “Nitric Oxide, Cytochromes P450, and Sexual
Steroid Hormones”, Springer.